SRSF4

Across TCGA cell cohorts, SRSF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,324 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRSF4-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Negative regulation of cell cycle process, and Spindle localization. Each is linked with SRSF4 in more than 15 cancer types. Because this analysis shows association rather than direction, both SRSF4-to-partner and partner-to-SRSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by SRSF4-low versus SRSF4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF4→partner) and Y-score (partner→SRSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of RNA splicing →	+0.105	+0.824	.001	.001	3	16
BREAST	Negative regulation of cell cycle process →	+0.060	+0.818	<.001	<.001	3	16
BONE	Spindle localization →	+0.096	+0.869	.002	.001	3	15
BLOOD_Leukemia	Mitotic sister chromatid segregation →	+0.085	+0.706	<.001	<.001	3	15
BONE	Centrosome cycle →	+0.079	+0.953	.002	<.001	3	15
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.100	+0.932	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,324 associations by consensus.

Negative regulation of RNA splicing by SRSF4 expression — URINARY_TRACT

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