SRSF12

Across TCGA patient cohorts, SRSF12 mutation is significantly associated with the RNA expression of many other genes, with 3,399 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF12-associated genes across cancer lineages are RNA5SP412, TRAV6, and TRDV1. Each is linked with SRSF12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRSF12-to-partner and partner-to-SRSF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by SRSF12-low versus SRSF12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF12→partner) and Y-score (partner→SRSF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.439	+1.967	.002	.005	3	3
UCEC	TRAV6 →	+0.342	+2.098	.007	.003	3	2
UCEC	TRDV1 →	+0.622	+2.310	<.001	.001	3	2
UCEC	PSAT1P4 →	+0.128	+1.978	.003	.001	3	2
UCEC	TOMM22P5 →	+0.163	+1.906	.006	.006	3	2
UCEC	LINC00458 →	+0.210	+2.068	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,399 associations by consensus.

RNA5SP412 by SRSF12 expression — UCEC

Explore this box plot interactively →