SRSF12

Across TCGA pan-cancer cohorts, SRSF12 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SRSF12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SRSF12 RNA is repressed in tumor relative to normal tissue. In most cancer types SRSF12 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LUAD, and KIRP are the cancer types where SRSF12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRSF12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−1.970	<.001	11	view →
LUAD	Male	II,III,IV	+1.049	<.001	10	view →
KIRP	All	IV	+1.547	<.001	9	view →
LUSC	Female	All	+1.353	<.001	8	view →
LIHC	All	II,III,IV	+0.343	<.001	8	view →
UCEC	All	II,III,IV	+1.105	.004	6	view →
BRCA	Female	All	−0.343	<.001	6	view →
COAD	All	All	−0.126	.004	5	view →
CHOL	All	All	+1.400	<.001	3	view →
BLCA	Male	IV	−0.747	.008	2	view →
HNSC	Male	IV	+0.710	.024	2	view →
KIRC	All	All	+0.246	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SRSF12–KICH

Open the KICH breakdown →