SRSF11

Across TCGA patient cohorts, SRSF11 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF11-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and ERK2. Each is linked with SRSF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF11-to-partner and partner-to-SRSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SRSF11-low versus SRSF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF11→partner) and Y-score (partner→SRSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.239	+2.199	.014	.033	3	2
UCEC	EGFR_pY1068 →	-0.187	-1.584	.038	.019	3	1
UCEC	ERK2 →	+0.141	+1.925	.042	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.127	-1.584	.004	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.127	-2.000	.036	.030	3	1
UCEC	JNK2 →	+0.172	+1.584	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

4E-BP1 by SRSF11 expression — UCEC

Explore this box plot interactively →