SRSF11

Across TCGA pan-cancer cohorts, SRSF11 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SRSF11 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SRSF11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRSF11 expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

ACC, LIHC, and LGG are the cancer types where SRSF11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.400	0.748	<.001	92	view →
LIHC	OS	Median	All	0.410	0.587	<.001	66	view →
LGG	DFS	Median	All	0.634	0.844	<.001	54	view →
KIRC	DFS	Tertile	II,III,IV	0.350	0.661	.001	48	view →
READ	OS	Median	II,III,IV	0.820	0.303	<.001	39	view →
UCS	DFS	Median	IV	0.952	0.367	.001	32	view →
UVM	DFS	Quartile	III,IV	0.183	0.735	.006	28	view →
GBM	DFS	Quartile	All	0.493	0.237	.012	21	view →
SARC	OS	Tertile	All	0.367	0.623	.001	18	view →
SKCM	OS	Median	IV	0.867	0.244	.006	17	view →
CHOL	DFS	Median	All	0.615	0.216	.014	15	view →
HNSC	OS	Median	All	0.748	0.621	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SRSF11–ACC (DFS)

Open the ACC breakdown →