SRSF11

Across TCGA cell cohorts, SRSF11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,500 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SRSF11-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Regulation of mRNA processing, and Viral transcription. Each is linked with SRSF11 in more than 16 cancer types. Because this analysis shows association rather than direction, both SRSF11-to-partner and partner-to-SRSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by SRSF11-low versus SRSF11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF11→partner) and Y-score (partner→SRSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of mRNA splicing, via spliceosome →	+0.112	+1.295	<.001	<.001	3	17
OESOPHAGUS	Regulation of mRNA processing →	+0.101	+1.093	.001	.001	3	17
STOMACH	Viral transcription →	+0.125	+0.869	<.001	<.001	3	16
BONE	Negative regulation of DNA-templated transcription initiation →	+0.173	+1.464	<.001	<.001	3	16
OESOPHAGUS	Spliceosomal complex assembly →	+0.120	+0.884	.001	<.001	3	16
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.119	+1.066	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,500 associations by consensus.

Regulation of mRNA splicing, via spliceosome by SRSF11 expression — BONE

Explore this box plot interactively →