SRSF11

Across TCGA cell cohorts, SRSF11 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRSF11-associated genes across cancer lineages are OPN1LW, ZNF831, and SCGB2A1. Each is linked with SRSF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF11-to-partner and partner-to-SRSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN1LW grouped by SRSF11-low versus SRSF11-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF11→partner) and Y-score (partner→SRSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OPN1LW →	+0.009	+4.754	<.001	.005	3	1
CNS	ZNF831 →	+0.088	+4.832	<.001	.002	3	1
CNS	SCGB2A1 →	+0.327	+4.169	<.001	.008	3	1
CNS	HTR5A →	+0.044	+4.472	<.001	.004	3	1
CNS	IL22RA2 →	+0.529	+4.169	<.001	.008	3	1
CNS	RPL10L →	+1.070	+4.169	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OPN1LW by SRSF11 expression — CNS

Explore this box plot interactively →