SRRT

Across TCGA pan-cancer cohorts, SRRT mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRRT data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRRT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SRRT expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

HNSC, COAD, and PDAC are the cancer types where SRRT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.787	0.904	.007	24	view →
COAD	DFS	Median	II,III,IV	1.000	0.885	.026	12	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	11	view →
LSCC	OS	Median	All	1.000	0.926	.017	8	view →
LUAD	DFS	Median	All	0.967	0.864	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRRT–HNSC (OS)

Open the HNSC breakdown →