SRRD

Across TCGA patient cohorts, SRRD mutation is significantly associated with the RNA expression of many other genes, with 1,658 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRD-associated genes across cancer lineages are LINC00624, PRAMEF13, and RNA5S17. Each is linked with SRRD in more than 1 cancer types. Because this analysis shows association rather than direction, both SRRD-to-partner and partner-to-SRRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00624 grouped by SRRD-low versus SRRD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRD→partner) and Y-score (partner→SRRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00624 →	+0.482	+3.545	.001	.002	3	1
UCEC	PRAMEF13 →	+0.029	+3.231	<.001	.004	3	1
BRCA	RNA5S17 →	+0.239	+9.057	<.001	.003	3	1
BRCA	RNU6-215P →	+0.267	+7.731	<.001	.009	3	1
BRCA	SNORA75B →	+0.263	+8.471	<.001	.005	3	1
BRCA	MTND4P17 →	+0.214	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,658 associations by consensus.

LINC00624 by SRRD expression — UCEC

Explore this box plot interactively →