SRRD

Across TCGA pan-cancer cohorts, SRRD RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SRRD data layer compared with 3 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SRRD RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRRD expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

CESC, LIHC, and ACC are the cancer types where SRRD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.148	0.893	<.001	74	view →
LIHC	OS	Tertile	All	0.549	0.753	<.001	65	view →
ACC	DFS	Tertile	All	0.165	0.769	<.001	55	view →
PAAD	OS	Quartile	II,III,IV	0.221	0.459	.006	44	view →
BRCA	DFS	Quartile	III,IV	0.926	0.773	.004	38	view →
HNSC	OS	Median	All	0.456	0.750	<.001	37	view →
ESCA	OS	Quartile	II,III,IV	0.914	0.653	.005	31	view →
LGG	DFS	Quartile	All	0.899	0.725	.001	23	view →
LUSC	DFS	Tertile	III,IV	0.425	1.000	.002	18	view →
GBM	DFS	Median	All	0.383	0.187	.003	18	view →
THCA	OS	Quartile	All	0.760	1.000	.007	13	view →
UCS	OS	Tertile	IV	0.675	0.225	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SRRD–CESC (DFS)

Open the CESC breakdown →