SRPX

Across TCGA pan-cancer cohorts, SRPX mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRPX data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SRPX mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SRPX expression acts as an unfavorable survival marker.

CCRCC, UCEC, and LUAD are the cancer types where SRPX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.233	0.891	<.001	31	view →
UCEC	OS	Quartile	III,IV	0.262	1.000	.016	20	view →
LUAD	DFS	Quartile	III,IV	0.460	0.996	.008	16	view →
LSCC	OS	Tertile	All	0.884	1.000	.011	12	view →
HNSC	OS	Median	II,III,IV	0.949	1.000	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRPX–CCRCC (OS)

Open the CCRCC breakdown →