SRPRB

Across TCGA pan-cancer cohorts, SRPRB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRPRB data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SRPRB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SRPRB expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where SRPRB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.695	0.936	.001	42	view →
HNSC	DFS	Tertile	All	0.777	0.491	<.001	36	view →
LUAD	DFS	Tertile	All	0.999	0.833	.001	11	view →
GBM	OS	Median	All	0.432	0.645	.005	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.563	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRPRB–CCRCC (OS)

Open the CCRCC breakdown →