SRPRB

Across TCGA patient cohorts, SRPRB mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible SRPRB-associated genes across cancer lineages are RNU6-693P, RNU6-1059P, and MIR7159. Each is linked with SRPRB in more than 2 cancer types. Because this analysis shows association rather than direction, both SRPRB-to-partner and partner-to-SRPRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-693P grouped by SRPRB-low versus SRPRB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRB→partner) and Y-score (partner→SRPRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-693P →	+0.312	+6.268	<.001	.001	3	3
BRCA	RNU6-1059P →	+0.171	+7.471	<.001	.008	3	2
BRCA	MIR7159 →	+0.452	+5.317	<.001	.006	3	1
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	1
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	1
UCEC	MIR6846 →	+0.934	+3.748	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

RNU6-693P by SRPRB expression — BRCA

Explore this box plot interactively →