SRPRB

Across TCGA cell cohorts, SRPRB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,374 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SRPRB-associated GO terms across cancer lineages are SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, Cotranslational protein targeting to membrane, and SRP-dependent cotranslational protein targeting to membrane. Each is linked with SRPRB in more than 18 cancer types. Because this analysis shows association rather than direction, both SRPRB-to-partner and partner-to-SRPRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition grouped by SRPRB-low versus SRPRB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRB→partner) and Y-score (partner→SRPRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.166	+1.222	<.001	<.001	3	19
OESOPHAGUS	Cotranslational protein targeting to membrane →	+0.155	+1.033	<.001	.001	3	16
BONE	SRP-dependent cotranslational protein targeting to membrane →	+0.137	+0.765	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Ribosome localization →	+0.109	+0.744	<.001	.003	3	11
UPPER_AERODIGESTIVE_TRACT	Ribosomal subunit export from nucleus →	+0.109	+0.744	<.001	.003	3	11
BLOOD_Lymphoma	Protein targeting to ER →	+0.104	+1.042	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,374 associations by consensus.

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition by SRPRB expression — OESOPHAGUS

Explore this box plot interactively →