Across TCGA patient cohorts, SRPRA protein abundance is significantly associated with the RNA expression of many other genes, with 15,487 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SRPRA-associated genes across cancer lineages are STT3A, FANCM, and EXD2. Each is linked with SRPRA in more than 5 cancer types. Because this analysis shows association rather than direction, both SRPRA-to-partner and partner-to-SRPRA results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRA→partner) and Y-score (partner→SRPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STT3A →	+0.615	+0.342	<.001	<.001	3	6
LSCC	FANCM →	-0.419	-0.178	.002	.005	3	6
BRCA	EXD2 →	-0.523	-0.397	<.001	<.001	3	6
OV	PNN →	-0.475	-0.251	<.001	<.001	3	6
GBM	AP4S1 →	-0.489	-0.324	<.001	<.001	3	5
CCRCC	CDKL1 →	-0.451	-0.205	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,487 associations by consensus.

Exploration

SRPRA survival (RNA) · tumor vs normal (RNA) · all SRPRA data types