Across TCGA patient cohorts, SRPRA mutation is significantly associated with the RNA expression of many other genes, with 4,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPRA-associated genes across cancer lineages are RNA5SP519, LINC02219, and MIR4452. Each is linked with SRPRA in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPRA-to-partner and partner-to-SRPRA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRA→partner) and Y-score (partner→SRPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP519 →	+0.295	+4.513	<.001	.009	3	2
BRCA	LINC02219 →	+0.318	+3.782	<.001	.007	3	2
BRCA	MIR4452 →	+0.439	+4.431	<.001	.008	3	2
BLCA	RNU6-650P →	+0.307	+4.038	<.001	.002	3	2
BRCA	RN7SL65P →	+0.645	+4.080	<.001	.004	3	2
COAD	TRAJ21 →	+1.284	+3.993	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,962 associations by consensus.

Exploration

SRPRA survival (RNA) · tumor vs normal (RNA) · all SRPRA data types