Across TCGA patient cohorts, SRPRA mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPRA-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and EGFR. Each is linked with SRPRA in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPRA-to-partner and partner-to-SRPRA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRA→partner) and Y-score (partner→SRPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.045	+1.331	.048	.017	3	2
UCEC	EGFR_pY1068 →	-0.261	-2.662	<.001	<.001	3	1
UCEC	EGFR →	-0.105	-1.674	.032	.040	3	1
UCEC	A-Raf_pS299 →	-0.117	-1.263	.001	.019	3	1
UCEC	ERK2 →	+0.132	+1.064	.025	.048	3	1
UCEC	GATA6 →	-0.131	-1.452	.009	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

SRPRA survival (RNA) · tumor vs normal (RNA) · all SRPRA data types