Across TCGA cell cohorts, SRPRA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRPRA-associated GO terms across cancer lineages are Positive regulation of early endosome to late endosome transport, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Endoplasmic reticulum to cytosol transport. Each is linked with SRPRA in more than 11 cancer types. Because this analysis shows association rather than direction, both SRPRA-to-partner and partner-to-SRPRA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRA→partner) and Y-score (partner→SRPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of early endosome to late endosome transport →	+0.141	+0.719	<.001	<.001	3	12
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.158	+0.477	<.001	.007	3	12
BONE	Endoplasmic reticulum to cytosol transport →	+0.130	+0.812	.006	.004	3	11
BONE	Retrograde protein transport, ER to cytosol →	+0.130	+0.812	.006	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular transport →	+0.058	+0.818	.002	.006	2	12
UPPER_AERODIGESTIVE_TRACT	Cotranslational protein targeting to membrane →	+0.115	+1.079	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,294 associations by consensus.

Exploration

SRPRA survival (RNA) · tumor vs normal (RNA) · all SRPRA data types