Across TCGA cell cohorts, SRPRA mutation is significantly associated with the RNA expression of many other genes, with 1,771 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRPRA-associated genes across cancer lineages are TTLL10, OR10A5, and OR9G1. Each is linked with SRPRA in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPRA-to-partner and partner-to-SRPRA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRA→partner) and Y-score (partner→SRPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TTLL10 →	+0.153	+4.584	<.001	.001	3	1
CNS	OR10A5 →	+0.018	+3.832	.003	.005	3	1
CNS	OR9G1 →	+0.022	+4.772	<.001	.002	3	1
CNS	OR10G7 →	+0.008	+4.772	<.001	.002	3	1
CNS	LCE3E →	+0.244	+4.169	<.001	.008	3	1
CNS	ZPBP2 →	+0.052	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,771 associations by consensus.

Exploration

SRPRA survival (RNA) · tumor vs normal (RNA) · all SRPRA data types