SRPRA

mutation — cross-omics
Cross-omicsMUTATION → MUTATIONCell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, SRPRA mutation is significantly associated with the mutation status of many other genes, with 4,441 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRPRA-associated genes across cancer lineages are TXNRD2, IFT172, and ABCA2. Each is linked with SRPRA in more than 3 cancer types. Because this analysis shows association rather than direction, both SRPRA-to-partner and partner-to-SRPRA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRA→partner) and Y-score (partner→SRPRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLOOD_LeukemiaTXNRD2 →+4.560+4.309.007.00714
BLOOD_LeukemiaIFT172 →+3.560+5.209<.001<.00114
BLOOD_LeukemiaABCA2 →+2.390+4.198.003.00314
LARGE_INTESTINETAF5L →+3.029+2.269<.001<.00114
BLOOD_LeukemiaEBF3 →+2.975+3.794.006.00614
BLOOD_LeukemiaING1 →+4.560+5.845<.001<.00113
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,441 associations by consensus.

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