SRPK3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SRPK3 mutation is significantly associated with the RNA expression of many other genes, with 3,638 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPK3-associated genes across cancer lineages are TRBV10-2, RNU6-183P, and RNU6-1149P. Each is linked with SRPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPK3-to-partner and partner-to-SRPK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK3→partner) and Y-score (partner→SRPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTRBV10-2 →+0.337+1.495<.001.00432
CESCRNU6-183P →+0.283+5.569<.001<.00132
BLCARNU6-1149P →+0.682+3.642<.001.00932
BRCARNU6-543P →+0.283+8.055<.001.00732
BRCARNA5SP100 →+0.277+8.055<.001.00732
CESCMIR5700 →+0.465+4.306<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,638 associations by consensus.

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