SRPK3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SRPK3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPK3-associated genes across cancer lineages are 14-3-3_beta, VHL, and ATM. Each is linked with SRPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPK3-to-partner and partner-to-SRPK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK3→partner) and Y-score (partner→SRPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCEC14-3-3_beta →-0.096-3.780.002<.00132
UCECVHL →-0.847-1.362<.001.03432
UCECATM →-0.591-2.378<.001<.00132
UCECDi-Ras3 →-0.166-3.893<.001<.00132
UCECeEF2 →+0.312+1.807.006.02431
UCECEGFR_pY1068 →-0.249-1.777.001.00231
Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration