Across TCGA cell cohorts, SRPK3 mutation is significantly associated with the mutation status of many other genes, with 3,079 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRPK3-associated genes across cancer lineages are DDX21, OR5B3, and SYT12. Each is linked with SRPK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRPK3-to-partner and partner-to-SRPK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK3→partner) and Y-score (partner→SRPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDX21 →	+5.560	+4.736	.003	.003	1	3
LUNG_NSCLC_LUAD	OR5B3 →	+5.339	+4.772	.004	.004	1	3
LUNG_NSCLC_LUAD	SYT12 →	+5.339	+4.772	.004	.004	1	3
SKIN	MYO1C →	+4.392	+4.392	.009	.009	1	3
BLOOD_Leukemia	TRIM10 →	+5.560	+4.736	.003	.003	1	3
LUNG_NSCLC_LUAD	OR2W3 →	+3.339	+4.662	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,079 associations by consensus.

Exploration

SRPK3 survival (RNA) · tumor vs normal (RNA) · all SRPK3 data types