SRPK1

Across TCGA pan-cancer cohorts, SRPK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRPK1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SRPK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SRPK1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where SRPK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.975	0.902	.006	19	view →
UCEC	DFS	Quartile	III,IV	1.000	0.270	.008	16	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	11	view →
PDAC	OS	Median	All	0.390	0.565	.016	9	view →
LUAD	DFS	Median	III,IV	0.716	0.332	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRPK1–LSCC (DFS)

Open the LSCC breakdown →