SRPK1

Across TCGA pan-cancer cohorts, SRPK1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of SRPK1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SRPK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SRPK1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

LUAD, LIHC, and COAD are the cancer types where SRPK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRPK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.751	<.001	11	view →
LIHC	Male	II,III,IV	+1.275	<.001	9	view →
COAD	Male	II,III,IV	+0.988	<.001	9	view →
LUSC	Male	II,III,IV	+1.561	<.001	8	view →
STAD	Male	II,III,IV	+1.126	<.001	8	view →
BRCA	All	II,III,IV	+0.916	<.001	8	view →
HNSC	Male	All	+0.598	<.001	8	view →
KIRC	All	II,III,IV	−0.368	<.001	8	view →
BLCA	All	III,IV	+0.790	.001	7	view →
UCEC	All	II,III,IV	+1.304	<.001	6	view →
CHOL	Male	All	+2.475	<.001	5	view →
KICH	Female	All	−1.076	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

SRPK1–LUAD

Open the LUAD breakdown →