SRPK1

Across TCGA patient cohorts, SRPK1 mutation is significantly associated with the RNA expression of many other genes, with 1,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPK1-associated genes across cancer lineages are ZWINT, DONSON, and HIRA. Each is linked with SRPK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRPK1-to-partner and partner-to-SRPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by SRPK1-low versus SRPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK1→partner) and Y-score (partner→SRPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.519	+1.988	.007	.008	3	3
UCEC	DONSON →	+0.361	+2.423	.009	.001	3	3
UCEC	HIRA →	+0.388	+3.617	.001	.001	3	2
UCEC	SGSM3 →	+0.366	+3.584	.004	.002	3	2
UCEC	NUTF2 →	+0.375	+1.970	<.001	<.001	3	2
UCEC	DHODH →	+0.383	+3.764	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,435 associations by consensus.

ZWINT by SRPK1 expression — UCEC

Explore this box plot interactively →