SRPK1

Across TCGA patient cohorts, SRPK1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPK1-associated genes across cancer lineages are p62 Lck ligand, S6_pS240_S244, and ATM. Each is linked with SRPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPK1-to-partner and partner-to-SRPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SRPK1-low versus SRPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK1→partner) and Y-score (partner→SRPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.319	+1.495	.005	.034	3	2
UCEC	S6_pS240_S244 →	+0.299	+2.222	.037	.010	3	2
UCEC	ATM →	-0.452	-1.362	.004	.037	3	2
UCEC	Cyclin-B1 →	+0.496	+2.321	.012	.034	3	2
UCEC	eIF4E →	+0.153	+3.013	.040	.018	3	1
UCEC	Fibronectin →	-0.243	-1.797	.037	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

p62 Lck ligand by SRPK1 expression — UCEC

Explore this box plot interactively →