SRPK1

Across TCGA cell cohorts, SRPK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,074 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRPK1-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, DNA replication initiation, and Mitotic G2 DNA damage checkpoint signaling. Each is linked with SRPK1 in more than 17 cancer types. Because this analysis shows association rather than direction, both SRPK1-to-partner and partner-to-SRPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by SRPK1-low versus SRPK1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK1→partner) and Y-score (partner→SRPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of RNA export from nucleus →	+0.125	+0.790	<.001	<.001	3	18
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.159	+0.932	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Mitotic G2 DNA damage checkpoint signaling →	+0.088	+0.770	<.001	<.001	3	16
BONE	'de novo' IMP biosynthetic process →	+0.130	+0.730	.004	<.001	3	15
BLOOD_Leukemia	DNA damage checkpoint signaling →	+0.062	+0.724	<.001	<.001	3	14
STOMACH	Lagging strand elongation →	+0.149	+0.649	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,074 associations by consensus.

Negative regulation of RNA export from nucleus by SRPK1 expression — KIDNEY

Explore this box plot interactively →