SRPK1

Across TCGA cell cohorts, SRPK1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRPK1-associated genes across cancer lineages are FAM236A, LUZP4, and VCY1B. Each is linked with SRPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPK1-to-partner and partner-to-SRPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM236A grouped by SRPK1-low versus SRPK1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPK1→partner) and Y-score (partner→SRPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	2
LUNG_SCLC	LUZP4 →	+1.000	+4.044	<.001	.009	3	1
BREAST	VCY1B →	+1.601	+4.421	<.001	.004	3	1
BREAST	VCY →	+0.925	+4.672	<.001	.002	3	1
BREAST	CLEC1B →	+0.013	+4.199	<.001	.007	3	1
BREAST	IL25 →	+0.032	+4.672	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM236A by SRPK1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →