SRP72

Across TCGA patient cohorts, SRP72 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP72-associated genes across cancer lineages are eIF4E, INPP4B, and JNK2. Each is linked with SRP72 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP72-to-partner and partner-to-SRP72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SRP72-low versus SRP72-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP72→partner) and Y-score (partner→SRP72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.160	+2.335	.038	.018	3	1
UCEC	INPP4B →	-0.281	-3.459	.018	.005	3	1
UCEC	JNK2 →	+0.271	+2.247	<.001	.001	3	1
UCEC	MEK1 →	+0.366	+3.807	.006	<.001	3	1
UCEC	Notch1 →	+0.122	+1.750	.017	.049	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.335	-2.584	.042	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by SRP72 expression — UCEC

Explore this box plot interactively →