SRP72

Across TCGA cell cohorts, SRP72 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRP72-associated genes across cancer lineages are RS1, IDI2, and KRT28. Each is linked with SRP72 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP72-to-partner and partner-to-SRP72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RS1 grouped by SRP72-low versus SRP72-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP72→partner) and Y-score (partner→SRP72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RS1 →	+0.006	+4.011	<.001	.009	3	2
OVARY	IDI2 →	+0.023	+4.029	<.001	.009	3	2
OVARY	KRT28 →	+0.039	+4.029	.003	.009	3	1
OVARY	DEFB116 →	+0.095	+4.807	<.001	.003	3	1
BREAST	OR2T5 →	+0.033	+5.781	<.001	.001	3	1
BREAST	C1orf141 →	+0.049	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RS1 by SRP72 expression — PANCREAS

Explore this box plot interactively →