SRP54-AS1

Across TCGA pan-cancer cohorts, SRP54-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SRP54-AS1 data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SRP54-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRP54-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUAD show a favorable association.

ACC, UVM, and KICH are the cancer types where SRP54-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.240	0.647	<.001	151	view →
UVM	DFS	Median	All	0.320	0.728	<.001	130	view →
KICH	DFS	Tertile	II,III,IV	0.408	1.000	.003	64	view →
LIHC	DFS	Tertile	All	0.491	0.662	.001	49	view →
BRCA	OS	Tertile	IV	0.845	0.291	.001	31	view →
COAD	OS	Quartile	All	0.833	0.946	.003	21	view →
ESCA	OS	Median	IV	0.222	0.698	.006	21	view →
KIRC	DFS	Median	IV	0.407	0.581	.011	20	view →
LUAD	OS	Quartile	All	0.872	0.775	.011	20	view →
PRAD	DFS	Median	All	0.621	0.883	<.001	18	view →
LUSC	OS	Median	All	0.729	0.623	.003	15	view →
MESO	OS	Quartile	All	0.571	0.305	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SRP54-AS1–ACC (DFS)

Open the ACC breakdown →