SRP54-AS1

Across TCGA pan-cancer cohorts, SRP54-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SRP54-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SRP54-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SRP54-AS1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KICH, and UCEC are the cancer types where SRP54-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRP54-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.387	<.001	8	view →
KICH	Female	II,III,IV	−1.091	<.001	6	view →
UCEC	All	All	+0.362	.008	4	view →
KIRC	Male	II,III,IV	+0.246	.001	4	view →
LIHC	All	All	+0.267	<.001	3	view →
LUSC	All	III,IV	−0.553	.002	2	view →
CHOL	All	All	+0.420	.004	2	view →
KIRP	All	All	+0.395	.003	2	view →
READ	All	II,III,IV	+0.482	.042	1	view →
LUAD	Female	II,III,IV	−0.382	.008	1	view →
THCA	Female	III,IV	+0.336	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SRP54-AS1–HNSC

Open the HNSC breakdown →