SRMS

Across TCGA patient cohorts, SRMS RNA expression is significantly associated with the go_rna of many other GO terms, with 7,149 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SRMS-associated GO terms across cancer lineages are Positive regulation of telomere maintenance, Positive regulation of establishment of protein localization to mitochondrion, and Regulation of establishment of protein localization to mitochondrion. Each is linked with SRMS in more than 20 cancer types. Because this analysis shows association rather than direction, both SRMS-to-partner and partner-to-SRMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomere maintenance grouped by SRMS-low versus SRMS-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRMS→partner) and Y-score (partner→SRMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Positive regulation of telomere maintenance →	+0.047	+1.109	.001	<.001	2	21
UCS	Positive regulation of establishment of protein localization to mitochondrion →	+0.057	+1.370	<.001	<.001	2	20
UCS	Regulation of establishment of protein localization to mitochondrion →	+0.042	+0.857	.003	.003	2	19
SCLC	Positive regulation of ruffle assembly →	+0.107	+0.532	.001	.006	1	20
SCLC	Positive regulation of DNA metabolic process →	+0.051	+0.735	.002	.003	1	20
MESO	Base-excision repair, gap-filling →	+0.038	+0.687	<.001	<.001	2	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,149 associations by consensus.

Positive regulation of telomere maintenance by SRMS expression — UCS

Explore this box plot interactively →