SRMS

Across TCGA pan-cancer cohorts, SRMS RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SRMS data layer compared with 10 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SRMS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SRMS expression acts as an unfavorable survival marker, although some lineages such as STAD and HNSC show a favorable association.

STAD, HNSC, and ACC are the cancer types where SRMS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Quartile	III,IV	0.707	0.472	.002	126	view →
HNSC	OS	Tertile	All	0.732	0.579	<.001	93	view →
ACC	DFS	Median	All	0.374	0.766	<.001	78	view →
UCEC	DFS	Median	II,III,IV	0.812	0.658	.004	58	view →
BLCA	OS	Tertile	All	0.779	0.637	.001	45	view →
UVM	DFS	Median	All	0.332	0.738	<.001	44	view →
COAD	DFS	Tertile	All	0.373	0.599	.001	43	view →
KIRC	DFS	Tertile	All	0.560	0.723	.009	35	view →
MESO	DFS	Quartile	II,III,IV	0.259	0.526	.004	24	view →
LAML	DFS	Tertile	All	0.170	0.533	.001	22	view →
THCA	DFS	Quartile	II,III,IV	0.734	0.953	.003	21	view →
CESC	DFS	Tertile	All	0.630	0.846	<.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SRMS–STAD (DFS)

Open the STAD breakdown →