SRMS

Across TCGA patient cohorts, SRMS mutation is significantly associated with the RNA expression of many other genes, with 2,481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRMS-associated genes across cancer lineages are LTV1P1, LINC01895, and LINC01957. Each is linked with SRMS in more than 1 cancer types. Because this analysis shows association rather than direction, both SRMS-to-partner and partner-to-SRMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LTV1P1 grouped by SRMS-low versus SRMS-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRMS→partner) and Y-score (partner→SRMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	LTV1P1 →	+0.096	+5.219	<.001	.006	3	2
READ	LINC01895 →	+0.500	+5.925	<.001	.002	3	2
GBM	LINC01957 →	+0.057	+4.857	<.001	.005	3	2
LGG	RNF11P2 →	+0.101	+5.327	<.001	.006	3	2
LGG	RPS20P25 →	+0.129	+6.032	<.001	.002	3	2
SKCM	DDX55 →	+0.675	+3.328	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,481 associations by consensus.

LTV1P1 by SRMS expression — READ

Explore this box plot interactively →