SRMS

Across TCGA patient cohorts, SRMS mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRMS-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with SRMS in more than 1 cancer types. Because this analysis shows association rather than direction, both SRMS-to-partner and partner-to-SRMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SRMS-low versus SRMS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRMS→partner) and Y-score (partner→SRMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.460	+2.584	.003	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.730	+2.479	.004	.010	3	2
UCEC	Cyclin-B1 →	+0.753	+2.807	.002	.003	3	2
UCEC	Ku80 →	+0.426	+3.920	<.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.186	-3.308	.004	.009	3	1
UCEC	N-Ras →	-0.116	-2.102	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MEK1 by SRMS expression — UCEC

Explore this box plot interactively →