SRMS

Across TCGA cell cohorts, SRMS RNA expression is significantly associated with the go_rna of many other GO terms, with 2,496 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible SRMS-associated GO terms across cancer lineages are Cilium movement involved in cell motility, Cytotoxic T cell degranulation, and Cilium or flagellum-dependent cell motility. Each is linked with SRMS in more than 8 cancer types. Because this analysis shows association rather than direction, both SRMS-to-partner and partner-to-SRMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium movement involved in cell motility grouped by SRMS-low versus SRMS-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRMS→partner) and Y-score (partner→SRMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cilium movement involved in cell motility →	-0.087	-1.221	<.001	<.001	3	9
BREAST	Cytotoxic T cell degranulation →	+0.256	+1.171	<.001	.004	3	8
LARGE_INTESTINE	Cilium or flagellum-dependent cell motility →	-0.084	-1.066	<.001	<.001	3	8
LARGE_INTESTINE	Cilium-dependent cell motility →	-0.084	-1.066	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	ERBB3 signaling pathway →	+0.161	+0.326	<.001	.008	3	8
UPPER_AERODIGESTIVE_TRACT	ERBB2-ERBB3 signaling pathway →	+0.161	+0.326	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,496 associations by consensus.

Cilium movement involved in cell motility by SRMS expression — LARGE_INTESTINE

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