SRMS

Across TCGA cell cohorts, SRMS mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRMS-associated genes across cancer lineages are C9orf92, PHOX2B, and TTLL2. Each is linked with SRMS in more than 1 cancer types. Because this analysis shows association rather than direction, both SRMS-to-partner and partner-to-SRMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by SRMS-low versus SRMS-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRMS→partner) and Y-score (partner→SRMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.021	+4.365	<.001	.002	3	1
BLOOD_Leukemia	TTLL2 →	+0.368	+3.736	<.001	.005	3	1
BLOOD_Leukemia	APOL5 →	+0.011	+3.475	.001	.006	3	1
BLOOD_Leukemia	TSHB →	+0.206	+3.691	<.001	.002	3	1
BLOOD_Leukemia	CRYGC →	+0.017	+3.969	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

C9orf92 by SRMS expression — SOFT_TISSUE

Explore this box plot interactively →