SRI-AS1

Across TCGA pan-cancer cohorts, SRI-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SRI-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SRI-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SRI-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

BRCA, KIRP, and UCS are the cancer types where SRI-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.903	0.757	<.001	69	view →
KIRP	OS	Tertile	III,IV	0.337	0.725	.003	62	view →
UCS	OS	Median	II,III,IV	0.686	0.224	.001	50	view →
KIRC	DFS	Tertile	III,IV	0.322	0.618	<.001	39	view →
COAD	DFS	Quartile	All	0.837	0.714	.006	32	view →
ACC	DFS	Median	IV	0.150	0.540	.001	28	view →
UVM	OS	Median	All	0.780	1.000	.012	27	view →
LUSC	DFS	Median	II,III,IV	0.300	0.671	.006	24	view →
HNSC	DFS	Tertile	IV	0.453	0.279	.005	20	view →
OV	DFS	Median	All	0.192	0.129	.015	20	view →
LIHC	DFS	Quartile	II,III,IV	0.225	0.503	.015	18	view →
BLCA	OS	Median	III,IV	0.747	0.620	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SRI-AS1–BRCA (OS)

Open the BRCA breakdown →