SRI-AS1

Across TCGA pan-cancer cohorts, SRI-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SRI-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SRI-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SRI-AS1 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

KIRP, BLCA, and THCA are the cancer types where SRI-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRI-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+0.362	.009	6	view →
BLCA	Female	III,IV	+0.342	.010	6	view →
THCA	Female	All	−0.136	<.001	4	view →
KIRC	All	All	+0.095	.002	3	view →
READ	Male	All	−1.486	.047	2	view →
BRCA	All	III,IV	−0.217	.021	2	view →
ESCA	All	All	+0.427	.037	1	view →
KICH	All	III,IV	+0.160	.048	1	view →
CHOL	All	All	+0.127	.049	1	view →
HNSC	All	III,IV	+0.098	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SRI-AS1–KIRP

Open the KIRP breakdown →