SRGAP3-AS4

Across TCGA pan-cancer cohorts, SRGAP3-AS4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SRGAP3-AS4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SRGAP3-AS4 RNA is repressed in tumor relative to normal tissue. In most cancer types SRGAP3-AS4 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where SRGAP3-AS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRGAP3-AS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.894	<.001	12	view →
KICH	Male	All	−1.518	<.001	10	view →
THCA	Female	II,III,IV	−0.798	<.001	10	view →
LUSC	All	II,III,IV	−0.258	<.001	7	view →
HNSC	All	All	−0.199	.001	6	view →
KIRP	All	All	−0.447	.003	5	view →
BRCA	All	All	+0.203	.007	5	view →
LIHC	All	All	+0.253	.001	4	view →
CHOL	All	II,III,IV	−0.240	.006	2	view →
COAD	Female	II,III,IV	−0.064	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SRGAP3-AS4–KIRC

Open the KIRC breakdown →