SRFBP1

Across TCGA patient cohorts, SRFBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,976 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRFBP1-associated genes across cancer lineages are NDUFA5P3, MIR7702, and RNU6-1299P. Each is linked with SRFBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRFBP1-to-partner and partner-to-SRFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA5P3 grouped by SRFBP1-low versus SRFBP1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRFBP1→partner) and Y-score (partner→SRFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	NDUFA5P3 →	+0.188	+4.289	<.001	.002	3	2
UCEC	MIR7702 →	+0.202	+4.060	<.001	.006	3	2
SKCM	RNU6-1299P →	+0.416	+5.594	<.001	.004	3	2
SKCM	YY1P2 →	+0.055	+6.993	<.001	<.001	3	2
UCEC	IGHD2-2 →	+1.890	+2.302	<.001	<.001	3	2
UCEC	MRPS9-AS2 →	+0.362	+2.321	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,976 associations by consensus.

NDUFA5P3 by SRFBP1 expression — LIHC

Explore this box plot interactively →