SRF

Across TCGA patient cohorts, SRF protein abundance is significantly associated with the RNA expression of many other genes, with 10,532 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SRF-associated genes across cancer lineages are GPRASP2, PDE5A, and PELI2. Each is linked with SRF in more than 3 cancer types. Because this analysis shows association rather than direction, both SRF-to-partner and partner-to-SRF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRF versus GPRASP2 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRF→partner) and Y-score (partner→SRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GPRASP2 →	+0.714	+0.453	<.001	<.001	3	4
HNSC	PDE5A →	+0.816	+0.452	<.001	<.001	3	4
HNSC	PELI2 →	+1.047	+0.321	<.001	<.001	3	4
UCEC	DAAM2 →	+0.627	+0.398	.002	.007	3	4
UCEC	CLEC1A →	+0.727	+0.675	<.001	<.001	3	4
UCEC	EMCN →	+1.080	+0.728	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,532 associations by consensus.

SRF vs GPRASP2 — HNSC

Explore this scatter interactively →