SRF

Across TCGA cell cohorts, SRF mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRF-associated genes across cancer lineages are OR11L1, BANF2, and NRAP. Each is linked with SRF in more than 1 cancer types. Because this analysis shows association rather than direction, both SRF-to-partner and partner-to-SRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11L1 grouped by SRF-low versus SRF-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRF→partner) and Y-score (partner→SRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11L1 →	+0.035	+4.981	<.001	.008	3	1
BLOOD_Lymphoma	BANF2 →	+0.071	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	NRAP →	+0.016	+4.927	<.001	.001	3	1
LARGE_INTESTINE	MMP26 →	+0.048	+4.217	<.001	.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.042	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OR9G1 →	+0.268	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR11L1 by SRF expression — CNS

Explore this box plot interactively →