SREBF1

Across TCGA patient cohorts, SREBF1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SREBF1-associated genes across cancer lineages are Lck, ERK2, and JNK2. Each is linked with SREBF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SREBF1-to-partner and partner-to-SREBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by SREBF1-low versus SREBF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF1→partner) and Y-score (partner→SREBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.190	+1.584	.008	.019	3	3
UCEC	ERK2 →	+0.160	+1.925	.020	.005	3	2
UCEC	JNK2 →	+0.203	+3.026	.004	.018	3	2
UCEC	p27_pT157 →	-0.062	-1.584	.002	.019	3	2
UCEC	Rictor_pT1135 →	-0.102	-2.000	.005	.030	3	2
UCEC	TFRC →	+0.466	+3.321	.014	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Lck by SREBF1 expression — UCEC

Explore this box plot interactively →