SREBF1

Across TCGA cell cohorts, SREBF1 mutation is significantly associated with the RNA expression of many other genes, with 723 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SREBF1-associated genes across cancer lineages are PPP2R5D, UCK1, and CYP4V2. Each is linked with SREBF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SREBF1-to-partner and partner-to-SREBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R5D grouped by SREBF1-low versus SREBF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF1→partner) and Y-score (partner→SREBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP2R5D →	+0.625	+3.234	.001	.004	3	2
LARGE_INTESTINE	UCK1 →	+0.584	+2.628	.001	.002	3	2
LARGE_INTESTINE	CYP4V2 →	+1.109	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ZFYVE9 →	+0.767	+2.628	<.001	.002	3	2
LARGE_INTESTINE	TIGD3 →	+0.458	+3.459	<.001	.001	3	2
OESOPHAGUS	SLC10A2 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 723 associations by consensus.

PPP2R5D by SREBF1 expression — LARGE_INTESTINE

Explore this box plot interactively →