SRCIN1

Across TCGA cell cohorts, SRCIN1 mutation is significantly associated with the mutation status of many other genes, with 4,869 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRCIN1-associated genes across cancer lineages are CLCN1, ARHGEF12, and TAF3. Each is linked with SRCIN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SRCIN1-to-partner and partner-to-SRCIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLCN1 grouped by SRCIN1-low versus SRCIN1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRCIN1→partner) and Y-score (partner→SRCIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CLCN1 →	+4.429	+5.247	.005	.005	1	5
OVARY	ARHGEF12 →	+5.204	+4.082	<.001	<.001	1	5
BLOOD_Leukemia	TAF3 →	+3.338	+4.083	.003	.003	1	5
BLOOD_Leukemia	C10orf71 →	+6.145	+5.479	<.001	<.001	1	5
LARGE_INTESTINE	CFTR →	+2.874	+1.809	<.001	<.001	1	5
SKIN	DOCK10 →	+2.811	+2.811	.005	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,869 associations by consensus.

CLCN1 by SRCIN1 expression — BLOOD_Lymphoma

Explore this box plot interactively →