SQLE

Across TCGA patient cohorts, SQLE protein abundance is significantly associated with the RNA expression of many other genes, with 11,029 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SQLE-associated genes across cancer lineages are MSMO1, NTAQ1, and DHCR7. Each is linked with SQLE in more than 5 cancer types. Because this analysis shows association rather than direction, both SQLE-to-partner and partner-to-SQLE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SQLE versus MSMO1 in HNSC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SQLE→partner) and Y-score (partner→SQLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MSMO1 →	+0.797	+0.585	<.001	<.001	3	6
OV	NTAQ1 →	+0.564	+0.589	<.001	<.001	3	5
BRCA	DHCR7 →	+1.007	+0.583	<.001	<.001	3	5
HNSC	MVD →	+0.939	+0.834	<.001	<.001	2	6
HNSC	FDPS →	+0.773	+0.600	<.001	<.001	3	5
HNSC	IDI1 →	+0.665	+0.634	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,029 associations by consensus.

SQLE vs MSMO1 — HNSC

Explore this scatter interactively →