SQLE

Across TCGA patient cohorts, SQLE mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SQLE-associated genes across cancer lineages are JNK2, Caspase-8, and A-Raf_pS299. Each is linked with SQLE in more than 1 cancer types. Because this analysis shows association rather than direction, both SQLE-to-partner and partner-to-SQLE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SQLE-low versus SQLE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SQLE→partner) and Y-score (partner→SQLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.358	+3.196	<.001	.009	3	2
UCEC	Caspase-8 →	-0.270	-2.807	.014	.003	3	2
UCEC	A-Raf_pS299 →	-0.149	-3.321	.004	.010	3	1
UCEC	Heregulin →	-0.133	-3.321	.013	.010	3	1
UCEC	IGFBP2 →	-0.620	-3.000	.029	.036	3	1
UCEC	INPP4B →	-0.339	-2.700	.016	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by SQLE expression — UCEC

Explore this box plot interactively →